Identification of Serum Anti-GADD34 Antibody as a Common Marker of Diabetes Mellitus and Parkinson Disease

Source: OMICS International

Figure 1: Comparison of serum GADD34-Ab levels between HDs and patients. Patients included those with diabetes mellitus (DM) (a), acute-phase cerebral infarction (aCI) (b), or cardiovascular disease (CVD) (c). GST-GADD34 protein was used as the antigen. AlphaLISA-determined serum antibody levels after subtraction of the levels against those of control GST are shown as box-whisker plots displaying the 10^th, 20^th, 50^th, 80^th and 90^th percentiles. P values calculated using the Mannâ��Whitney U test are shown in a, c and e. The total (male/female) numbers, average values, standard deviations, cut-off values, positive numbers, positive rates (%) and P values obtained using student’s t test are summarized and shown in Tables 1-3. Receiver operating characteristic curve (ROC) analysis was performed to assess the abilities of s-GADD34-Abs to detect DM, aCI and CVD (b, d and f). Numbers in the figures indicate the area under the curve (AUC), 95% confidence intervals (CI), and cutoff values for marker levels. Numbers within parentheses indicate sensitivity (left) and specificity (right).

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