Topic Overview

Many medicines seem to be related to bone fractures or to bone thinning (osteoporosis) that can lead to fractures. These medicines include:

  • Corticosteroid medicines. These are used to treat conditions such as
    asthma and
    chronic obstructive pulmonary disease (COPD). If you use them for 6 months or longer, they can lead to
    steroid-induced osteoporosis.
  • Thyroid replacement medicine, if
    the dose is more than the body needs. This should be monitored by checking the
    level of thyroid-stimulating hormone (TSH) at least every year.
  • Antiseizure medicines. Examples are carbamazepine and phenytoin.
  • Medicines used to treat
    endometriosis. They include leuprolide (Lupron) and
    nafarelin (Synarel).
  • Aromatase inhibitors. These are used
    to treat
    breast cancer.
  • Hormone therapy to treat prostate cancer.
  • Some
    antidepressant medicines called selective serotonin reuptake inhibitors
    (SSRIs). SSRIs are used to treat many
    conditions, including
    fibromyalgia, and
    premenstrual syndrome.
  • Heparin, if used for a long
    time. Heparin is a blood thinner.
  • Depo-Provera, if
    used for a long time. It’s a birth control medicine given in a shot.
  • Antacids that contain aluminum, if they are overused.
    These kinds of antacids remove calcium from your
  • Some diabetes medicines. Examples are pioglitazone (Actos) and rosiglitazone (Avandia).


ByHealthwise Staff
Primary Medical Reviewer Kathleen Romito, MD – Family Medicine
Specialist Medical Reviewer Carla J. Herman, MD, MPH – Geriatric Medicine

Current as ofMay 4, 2017