People who are infected with hepatitis B virus (HBV) or hepatitis C (HCV) virus may develop a chronic
infection that can lead to cirrhosis. The damage that results increases the risk
of liver cancer (hepatocellular carcinoma).
If you have chronic HBV infection:
You may develop liver cancer even if you do not
have cirrhosis. But most people who have HBV and liver cancer also have
Receiving antiviral therapy to treat chronic HBV
infection may lower your risk for developing liver cancer.
If you have chronic HCV infection:
The strain (genotype) of HCV infection does not
appear to affect your risk for developing liver cancer.
You are not
at significant risk of developing cancer unless you also already have
You are at greatly increased risk of liver cancer if you
have alcohol-related cirrhosis in addition to hepatitis.
antiviral therapy to treat chronic HCV infection may lower your risk for
developing liver cancer.
Screening with ultrasound of the liver, liver function tests, and
blood tests (including alpha-fetoprotein [AFP]) every 6 to 12 months is
recommended for people at risk of liver cancer.
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Ciesek S, Manns MP (2015). Chronic liver diseases. In EG Nabel et al., eds., Scientific American Medicine, chap. 1033. Hamilton, ON: BC Decker. https://www.deckerip.com/decker/scientific-american-medicine/chapter/1033/pdf. Accessed November 21, 2016.
ByHealthwise Staff Primary Medical ReviewerKathleen Romito, MD – Family Medicine Adam Husney, MD – Family Medicine E. Gregory Thompson, MD – Internal Medicine Specialist Medical ReviewerW. Thomas London, MD – Hepatology