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What is de Quervain's tenosynovitis? De Quervain's (say "duh-kair-VANZ") tenosynovitis, also called De Quervain's, is a problem that makes the bottom of your thumb and the side of your wrist hurt. When you have de Quervain's, the ropey fiber ( tendon ) that helps move your thumb away from your fingers becomes swollen...