enhancing kcc2 function counteracts morphine induced hyperalgesia

Our data indicate that enhancing KCC2 activity is a viable therapeutic approach for counteracting MIH. Paradoxical morphine-induced hyperalgesia (MIH) is a form of nociceptive sensitization in which subjects exposed to morphine treatment develop a paradoxical increased pain sensitivity or exacerbate pre-existing pain1, 2. We recently identified a microglia-to-neuron pathway in the spinal dorsal horn which...