increased liver ages induce hepatic injury mediated through an ost48 pathway

Hepatic ER stress and AGE accumulation are each implicated in liver injury. By week 24 of the study, either increasing OST48 expression or consumption of high AGE diet impaired liver function and modestly increased hepatic fibrosis, but their combination significantly exacerbated liver injury in the absence of steatosis. This study revealed a novel role of...