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Many nonprescription and prescription medicines and supplements can cause gas and bloating. A few examples are: Aspirin. Antacids. Diarrhea medicines, such as Imodium, Kaopectate, and Lomotil. Opioid pain medicines. Fiber supplements and bulking agents, such as Citrucel, Fiberall, and Metamucil. Multivitamins and iron...