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What is myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)? Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) (say "my-AL-jik en-seh-fuh-loh-my-uh-LY-tus") is a condition that makes you feel so tired that you can't do all of your normal, daily activities. There are other symptoms too, but being very...