a novel mouse model of inkt cell deficiency generated by crisprcas9 reveals a pathogenic role of inkt cells in metabolic disease

All four Traj18-partial deletion mouse lines harbored similar Traj gene segments as WT B6 mice, except for Traj18 (Fig. (a) TCRα repertoire diversity analyzed by next generation sequencing. Frequencies of iNKT cells in the spleen and liver from WT B6 and Traj18−/− (1-1 L) mice were analyzed by flow cytometry, which revealed iNKT cell-deficiency in...