ethanol triggered lipophagy requires sqstm1 in aml12 hepatic cells

We found that both LC3 and SQSTM1 could colocalize with lipid droplets (LDs) following ethanol treatment. In addition, increased ubiquitin signals were found to colocalize with SQSTM1 on LDs in response to ethanol. Hepatic triglycerides (TG) level in alcoholic fatty liver disease models was reduced by activating autophagy, and was elevated when autophagy was inhibited5,6....