hiv 1 viral protein r vpr induces fatty liver in mice via lxrα and pparα dysregulation implications for hiv specific pathogenesis of nafld

HIV patients develop hepatic steatosis. Vpr enhanced association of LXRα with Lxrα and Srebp1c promoters, increased LXRE-LXRα binding, and broadly altered hepatic expression of LXRα-regulated lipid metabolic genes. (A) Immunoblots show expression of transcription factors and their target proteins in Vpr-Tg vs. WT mice (N = 4 per group). (F) Immunoblots show expression of transcription...