lack of nlrp3 inflammasome leads to gut liver axis derangement gut dysbiosis and a worsened phenotype in a mouse model of nafld

(Fig. (Fig. According to NLRP3-inflammasome deficiency and diet, significant differences between microbial taxa were found (Fig. Effect of diet and genotype on gut microbiota composition. 7d) and this was associated with reduced TLR4, TLR5 and TLR9 expression in the liver of Nlrp3−/−-HFHC mice (Fig. The worsen degree of adipose tissue inflammation and liver injury in...