macrophage vldlr mediates obesity induced insulin resistance with adipose tissue inflammation

Moreover, elevated VLDLR protein was detected in CD11b+ ATMs from obese adipose tissues (Fig. These data suggested that macrophage VLDLR could potentiate M1-like macrophage polarization by uptaking VLDL. Although it has been shown that elevated circulating ceramides would confer systemic insulin resistance40, 41, the levels of secreted ceramides were not different in CM from WT...