microrna regulation of cyp 1a2 cyp3a4 and cyp2e1 expression in acetaminophen toxicity

MicroRNAs (miRNAs) that regulate the cytochrome P-450 isoforms involved in acetaminophen (APAP) toxicity were examined in HepaRG cells treated with APAP (20 mM). Thus, the in-vitro experiments showed that miR-122-5p and miR-378a-5p upregulation were associated with translational repression of CYPs. Previous reports have described a role for microRNAs (miRNAs) in the regulation of drug metabolizing...