non invasive assessment of hepatic mitochondrial metabolism by positional isotopomer nmr tracer analysis pinta

Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (VCS) and pyruvate carboxylase flux (VPC) in vivo. A key motivation for this study is to develop an alternative non-invasive tracer method to model hepatic...