therapeutic sirna targeting endothelial kdr decreases portosystemic collateralization in portal hypertension

These siRNAs were first validated in vitro, and then, their therapeutic potential on portosystemic collateralization and pathological angiogenesis was tested in vivo in mouse models of portal hypertension (portal vein-ligation). Full size image Intracellular localization of siRNA-Cy3-lipoplexes in the vascular endothelium of mesenteric microvessels and portal vein in portal hypertensive mice. S4 (H&E-stained mesenteric sections)....