What is ankylosing spondylitis?
arthritis that most often occurs in the spine. It can cause pain and stiffness in the low back, middle back, buttocks, and neck, and sometimes in other areas such as the , chest wall, or heels. It can also cause swelling and limited motion in these areas. This disease is more common in men than in women.(say "ang-kill-LOH-sing spawn-duh-LY-tus") is a long-term form of
There is no cure, but treatment can control symptoms and prevent the disease from getting worse in most cases. Most people are able to do their normal daily activities and can still work.
This disease can cause several other problems. You may have redness and pain in the colored part of your eye (iritis). You also may have trouble breathing as your upper body begins to curve and your chest wall begins to stiffen.
What causes ankylosing spondylitis?
The cause is unknown, but it may run in families. Most people with gene, HLA-B27. But having this does not mean that you will get the disease.are born with a certain
Research suggests thatand your environment may have roles in causing this disease.
What are the symptoms?
This disease causes mild to severe pain in the low back and buttocks that is often worse in early morning. Some people have more pain in other areas, such as the hips or heels. The pain usually gets better slowly as you move around and are active.most often begins anywhere from the teenage years through the 30s.
It gets worse slowly over time as swelling of the join, or fuse, together. This leads to less range of movement in the neck and low back., , and of the causes the of the to
As the spine fuses and stiffens, the neck and low back lose their normal curve. The middle back curves outward. This can keep you in a bent-forward position and may make it hard for you to walk.
As the smallthat connect the ribs and collarbone to the get inflamed, you may find that it's harder for you to breathe. Other parts of the body, such as your eyes and your other , may also swell. Sometimes the disease affects the , the heart valves, the , and the major blood vessel called the .
How is ankylosing spondylitis diagnosed?
The early signs of this diseaseâ€”dull pain in the low back and buttocksâ€”are common. Your doctor will ask about your symptoms and if they have become worse over time. Your doctor will also ask if you have aof this joint disease or others like it.
The clearest sign of the disease is a change in the sacroiliacat the base of the low back. This change can take up to a few years to show up on an .
How is it treated?
Treatment includes exercise and. These will help reduce stiffness so that you can stand up straighter and move around better. Your doctor will also give you medicine for pain and swelling.
Because people withmay be at a higher risk for , it's important that you wear a seat belt every time you drive or ride in a car.
You will need to get regular eye exams to check forin your eye, called . You may use a device such as a cane to help you walk and to help reduce on your .
Surgery for theis rarely needed. You may want to think about hip or knee replacements if you have severe in those .
There is no cure for this disease. But early diagnosis and treatment can help relieve pain and stiffness and allow you to keep doing your daily activities for as long as possible.
If thecontinues over time, it will lead to scarring and permanent damage. In some people the disease is mild and progresses slowly, and symptoms may never become severe. Other people may have a more aggressive disease process.
Whethergets worse depends on a number of things such as how old you were when the disease began, how early it was diagnosed, and what are involved. It's too early to tell yet, but experts hope that early treatment with newer medicines will slow or minimize the , prevent scarring, and limit the progression of the disease.
Mild or early ankylosing spondylitis
usually starts with dull pain in the low back and back stiffness. Some people with have "flares" of increased pain and stiffness that may last for several weeks before decreasing again.
- Affected of the low back, middle back, , or neck may become painful, stiff, and limited in motion. Pain tends to increase slowly over a period of weeks or months, and it is often hard to point to exactly where the pain is. Stiffness is usually worse in the morning and usually lasts for more than one hour. Pain is often noticeable in the early morning hours of sleep, such as between 3 a.m. and 6 a.m. Physical activity often helps decrease pain and stiffness.
- Some people feel tired as the disease progresses. This comes from the body fighting the inflammatory process that is part of and also from ongoing stiffness and pain.
- The colored part of the eye (iris) may become inflamed. Symptoms of include redness and pain in the eye and sensitivity to light.
Severe or advanced ankylosing spondylitis
If, over time, thecontinues, it will lead to scarring and permanent damage.
- Scarring in the spine causes the of the to grow together (fuse, or "ankylose").
- As the bones fuse, back pain will gradually go away, but the will remain very stiff and unable to bend. The fused is more likely to break (fracture) if injured, especially the neck (cervical spine).
- Changes in the spine can cause problems with balance, safety, and mobility. The upper can curve forward until eventually the person has a hard time looking straight ahead. Also, as the loses its natural curves, it becomes hard to balance while standing and walking, especially if the are also affected.
- Breathing can become difficult as the upper body curves forward and the chest wall stiffens. Severe pulmonary fibrosis) and an increased risk of infection. This can cause even greater problems in smokers, because their are already more prone to infection and scarring. can also cause scarring of the (
- Scarring in the eye from uncontrolled can lead to permanent visual impairment and glaucoma.
- In rare cases, the heart muscle can become scarred and the heart valves may become inflamed. The heart may be unable to pump properly (heart failure). The main leading from the heart (aorta) can also be affected by becoming inflamed and enlarged near where it leaves the heart.
- Bowel inflammation is sometimes linked with .
- The can be affected by taking medicines over a long period of time.
- Some people who have cauda equina syndrome from scarring around the nerves at the end of the spinal cord. This condition can cause of feeling in the saddle area of the groin and legs. It can also cause problems with bowel and bladder control and sexual activity. Talk to your doctor if you start having problems controlling your bowels or bladder. for many years develop
The stiffening of the chest can feel like the discomfort or "heaviness" of a. can also cause the heart to work less efficiently.
spondyloarthropathies(say "spon-dill-o-ar-THROP-a-thees"). These include psoriatic arthritis, reactive arthritis, and enteropathic arthritis (joint problems linked with inflammatory bowel disease). Although of the also occurs in these other conditions, it is less common and less severe than the that occurs in .is one disease in a of joint diseases called the
Exams and Tests
Your doctor will use a medical history,, and to diagnose .
By asking questions about your medical history, your doctor can evaluate your symptoms. Most people withhave back pain with four or five of the following characteristics:
- Begins before the of about 35
- Starts and gets worse gradually
- Persists for at least 3 months
- Is linked with morning stiffness that usually lasts for more than one hour
- Improves with exercise
Your doctor will want to know whether you have any family members who have cervix(in women) or urethra(more common in men), psoriasis, or inflammation of the eye chamber (uveitis). These could be clues to having a condition other than .or a related joint disease. Many people with have a family member with the same condition. He or she may also ask whether you have had ongoing diarrhea, abdominal (belly) pain, multiple infections of the
You will have ato see how stiff your back is and whether you can expand your chest normally. Your doctor will also look for tender areas, especially over the points of the , the pelvis, the areas where your ribs join your , and your heels. You may experience chest pain and stiffness with .
Tests related toinclude:
- X-rays of the spine and pelvis to check for bone changes (bony erosions, fusion, or calcification of the spine and sacroiliac joints). Certain changes in the sacroiliac joint confirm the diagnosis of . But those changes can take several years to develop enough to show on . MRI and CT scan are more sensitive than . If no changes to the sacroiliac show on the but your doctor still suspects , an MRI or CT scan may allow an earlier diagnosis. Ultrasound is being studied as a way to diagnose earlier.
- Blood tests. These may include:
- C-reactive protein (CRP) or sedimentation rate (sed rate) to look for .
- Rheumatoid factor or antinuclear antibody test (ANA) to look for other types of arthritis or illness.
- A genetic test, which may be done to determine the presence of a gene (HLA-B27) that is often linked with . Many people who have the HLA-B27 gene will not develop , so having this test will not confirm whether you have the condition. But the test results can be helpful if your symptoms and have not clearly pointed to a diagnosis.
Treatment for inflammation, keeping the condition from getting worse, and enabling you to continue daily activities. Early diagnosis and treatment may reduce pain, stiffness, , and deformity.focuses on relieving pain and stiffness, reducing
Talk with your doctor about the best treatment approach for your condition. A consultation with a rheumatologist is often recommended, especially to confirm the diagnosis and lay out a treatment plan. Your family medicine physician or internist can treat mild cases. Or you may be referred to a , orthopedist, or physiatrist.
Initial treatment formay include:
- Education, so you know what you can expect as progresses and how you can minimize problems that can be caused by your condition.
- Flexibility and strengthening exercises, to maintain mobility and control pain. People who exercise regularly find they have less pain and stiffness than those who are less active.
- Nonsteroidal anti-inflammatory drugs (NSAIDs), to relieve pain and stiffness, reduce , and help with . Some people seem to get more benefit from daily NSAIDs than from taking NSAIDs just when they notice symptoms. Talk to your doctor about using NSAIDs for , including how much to take and how often to take it.
- Physical therapy, to help you keep proper posture, and deep breathing exercises, to enhance your lung capacity. A physical therapist can also help you learn to use heat and cold to help control your pain and stiffness. Heat can help with relaxation and pain relief, and cold can help reduce .
- Assistive devices such as canes or walkers, which allow you to be physically active while reducing on .
- Alternative therapies such as yoga or acupuncture, which may help relieve pain and improve quality of life.
Talking with your doctor about your job. A job that is physically demandingâ€”such as a job that requires lots of heavy liftingâ€”could increase your symptoms.
If initial treatment does not sufficiently reduce the pain and inflammation linked with, and as your condition progresses, ongoing treatment may include:
- Flexibility and strengthening exercises, to maintain mobility and control pain. People who exercise regularly find they have less pain and stiffness than those who are less active. In addition to general flexibility and strengthening, walking and swimming are good activities for people who have . Some people continue to participate in sports also. Talk to your doctor or physical therapist about activities that will help you and that you will enjoy.
- Medicine. Doctors usually will first recommend nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain and inflammation. But you may need other, stronger medicines. Be safe with medicines. Read and follow all instructions on the label.
- Corticosteroids, which are similar to natural produced in the body, reduce . Corticosteroids are sometimes used for such as the , not for the of the .
- Disease-modifying antirheumatic drugs (DMARDs). Non-biologic , such as methotrexate or sulfasalazine, may help relieve pain in other than the spine and pelvis. Biologic , such as etanercept or infliximab, reduce by blocking harmful responses from the body's immune system that lead to the symptoms of .
- Physical therapy, to help you keep good posture, and deep breathing exercises, to enhance your capacity. A physical therapist can also help you learn to use heat and cold to help control your pain and stiffness. Heat can help with relaxation and pain relief, and cold can help reduce .
- Assistive devicessuch as canes or walkers, which allow you to maintain physical activity while reducing on .
- Alternative therapies such as yoga or acupuncture, which may help relieve pain and improve quality of life.
Treatment if the condition gets worse
In rare cases, you may need surgery to replace hip replacement surgery. Spine surgery is done in a very small number of people who have . If there is loosening of the top two vertebrae in the neck and there are signs of pressure on the spinal cord such as numbness or clumsiness in the hands or arms, a may permanently join (fuse) the two vertebrae together. In very rare cases, spinal surgery may be done to straighten a part of the that has become severely curved, but the surgery is risky and cannot restore motion.that are severely damaged by the of . The most common surgery done is
Even if your symptoms are under control, you should see your doctor (often a rheumatologist) every year to watch for and treat any complications. People with hip symptoms and perhaps those whose disease started in their teens may be at risk for a more severe progression of .
If you have been diagnosed with, there are steps that you can take at home to help reduce pain and stiffness and allow you to continue daily activities. These steps include:
- Educating yourself. Learn all you can about your condition and know what complications to watch for. This will help you control your symptoms and stay more active.
- Taking pain relievers such as nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce pain. If NSAIDs do not relieve your pain, try acetaminophen. Heat, such as warm showers or baths or sleeping under a warm electric blanket, may also reduce pain and stiffness.
Exercising regularly. This reduces pain and stiffness and helps maintain fitness and mobility of the , chest, and . Your doctor may recommend physical therapy to get you started on an exercise program.
- Deep breathing exercises can improve or help you keep your capacity.
- Swimming as part of your exercise program helps to maintain chest expansion and movement of the without jarring the . Breaststroke is especially good for chest expansion.
- You should avoid contact sports, because joint fusion may make your more likely to fracture as the disease progresses. Your doctor may approve of other activities such as golf and tennis. Check with your doctor before you add any new activity.
- Maintaining proper posture and chest expansion. Good posture is important because it can help prevent abnormal bending of the spine. Maintaining chest expansion may help prevent problems such as infection (pneumonia). It's a good idea to lie on your a few times each day to keep your spine and hips extended. For sleeping, choose a firm mattress and a small pillow that supports your neck. Try to lie flat on your back to sleep. If it's comfortable for you, you can also sleep part of the night on your .
- Using assistive devices such as canes or walkers. Your local chapter of the Arthritis Foundation, your physical therapist, or a medical supply company may be able to help you find in your area.
- Taking steps to protect yourself in the car, such as always using a seat belt. that are inflamed or damaged can easily be injured in an accident. If your neck is becoming stiff, your doctor may advise you to wear a soft when you ride in the car, to prevent injury in case of an accident.
- Avoiding smoking, to prevent serious breathing problems and lung scarring. Lung damage from smoking, combined with decreased chest expansion and the lung infections that sometimes go with , can seriously limit your ability to breathe freely.
- Seeing your doctor (often a rheumatologist) at least once each year, to check on your condition and watch for any complications. Catching complications early and treating them can prevent further problems.
- Having regular eye exams by an ophthalmologist, to check for of the colored part of the eye (iritis).
- Talking with your doctor about your job. A job that is physically demandingâ€”such as a job that requires lots of heavy liftingâ€”could increase your symptoms.
- Joining a support group. Ask your doctor about the types of support that are available where you live. Meeting other people with the same problems can help you know that you're not alone.
Other Works Consulted
- Deimel GW IV, Braverman SE (2015).. In WR Frontera et al., eds., Essentials of Physical Medicine and Rehabilitation, 3rd ed., pp. 609â€“613. Philadelphia: Saunders.
- Inman RD (2016). The. In L Goldman, A Shafer, eds., Goldman-Cecil Medicine, 24th ed., vol. 2, pp. 1762â€“1769. Philadelphia: Saunders.
- Van der Linden SM, et al. (2013).. In GS Firestein et al., eds., Kelley's Textbook of Rheumatology, 9th ed., vol. 2, pp. 1202â€“1220. Philadelphia: Saunders.
- Ward MM, et al. (2016). American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 recommendations for the treatment ofand nonradiographic axial spondyloarthritis. Arthritis and Rheumatology, 68(2): 282â€“298. DOI: 10.1002/art.39298. Accessed April 29, 2016.
ByHealthwise StaffPrimary Medical Reviewer E. Gregory Thompson, MD - Internal Medicine Adam Husney, MD - Family Medicine Martin J. Gabica, MD - Family Medicine Kathleen Romito, MD - Family Medicine Richa Dhawan, MD - Rheumatology
Current as ofOctober 10, 2017