Insulin for Type 1 and Type 2 Diabetes

Example(s): NovoLog (insulin aspart),Apidra (insulin glulisine),Afrezza (insulin human (inhalation powder)),Humalog (insulin lispro),Humulin R,Novolin R,Humulin R U-500 (insulin regular),Humulin N,Novolin N (insulin NPH),Levemir (insulin detemir),Lantus (insulin glargine),Humulin 70/30,Novolin 70/30 (70% NPH and 30%
regular),Humalog Mix 50/50 (50%
lispro protamine and 50% lispro),Humalog Mix 75/25 (75% lispro protamine and 25% lispro),NovoLog Mix 70/30 (70% aspart protamine and 30% aspart),Humulin 50/50 (50% NPH and 50% regular)

Insulin for Type 1 and Type 2 Diabetes


The different
types of insulin are categorized according to how fast
they start to work (onset) and how long they continue to work (duration). The
types now available include rapid-, short-, intermediate-, and long-acting


Generic Name Brand Name
insulin aspart NovoLog
insulin glulisine Apidra
insulin human (inhalation powder) Afrezza
insulin lispro Humalog


Generic Name Brand Name
insulin regular Humulin R, Novolin R, Humulin R U-500


Generic Name Brand Name
insulin NPH Humulin N, Novolin N


Generic Name Brand Name
insulin detemir Levemir
insulin glargine Lantus


Generic Name Brand Name
70% NPH and 30%
Humulin 70/30, Novolin 70/30
lispro protamine and 50% lispro
Humalog Mix 50/50
75% lispro protamine and 25% lispro Humalog Mix 75/25
70% aspart protamine and 30% aspart NovoLog Mix 70/30
50% NPH and 50% regular Humulin 50/50


Injectable insulin is packaged in small
glass vials (bottles) and cartridges that hold more than one
dose and are sealed with rubber lids. The cartridges are used in pen-shaped
devices called insulin pens.

Inhaled insulin is a powder that is packaged in a cartridge. Cartridges hold certain dosages of insulin, and more than one cartridge might be needed to take enough insulin.

How insulin is taken

Insulin usually is given as
an injection into the tissues under the skin (subcutaneous). It can also be
given through an
insulin pump, an
insulin pen, or jet injector, a device that sprays the
medicine into the skin. Some insulins can be given through a vein (only in a

Powdered insulin is packaged in a cartridge, which fits into an inhaler. Using the inhaler, a person breathes in to take the insulin.

How It Works

Insulin lets sugar (glucose) in the
blood enter cells, where it is used for energy. Without insulin, the blood
sugar level rises above what is safe for the body. If the cells don’t get sugar to use for energy, they try to use other nutrients in the body. When this happens, acids can build up. Too much acid production (ketoacidosis) can be serious or even life-threatening.

Your body uses
insulin in different ways. Sometimes you need insulin to work quickly to reduce
blood sugar. Your body also needs insulin on a regular basis to keep your blood
sugar in a target range.

  • Rapid-acting and short-acting insulins reduce
    blood sugar levels quickly and then wear off.
  • When you use
    intermediate- or long-acting insulin with rapid- or short-acting insulins, the longer acting
    insulin starts taking effect when the shorter acting insulin begins to wear
  • Usually people who take insulin use a combination of a
    rapid- or short-acting and an intermediate- or long-acting insulin. This can help to
    keep blood sugar levels within a range that is safe for the body throughout the

Why It Is Used

Insulin is used to treat:

  • People who have
    type 1 diabetes.
  • People with
    type 2 diabetes whose
    pancreas produces little or no insulin or whose other diabetes
    medicines do not control their blood sugar. These people may take insulin
    either by itself or along with other diabetes medicine.
  • People with type 2
    diabetes whose blood sugar levels are high because of a severe illness or major
    surgery. After blood sugar levels return to a target range, these people may be
    able to stop taking insulin.
  • Women with type 2 diabetes who are
    pregnant or breastfeeding and who cannot keep their blood sugar levels in a
    target range with diet and exercise. Sometimes other medicine for type 2 diabetes, such as metformin or glyburide, is used during pregnancy.

How Well It Works

Insulin is effective in reducing
blood sugar levels by helping sugar (glucose) enter the cells to be used for

Some things that affect
how fast and how well an insulin dose works are:

  • Where the dose is given. If you give insulin
    into your abdomen (especially above and to the side of your belly button), the
    medicine will get into your system more consistently from day to day. If the
    medicine is given into a muscle or a small blood vessel instead of fatty
    tissue, the medicine will get into your system faster.
  • How much
    insulin is given. Higher doses of insulin reduce the blood sugar level more
    than lower doses.
  • Whether you have exercised before or just after taking insulin.
    If you have just exercised the muscles in the area where you give your insulin
    injection, the medicine will get into your system faster.
  • If you
    apply heat to the area. The medicine will get into your system faster if you
    take a hot bath or shower, put on a heat pack, or massage the area where you
    have just given your insulin injection.
  • If you do not have enough
    fluid in your body (you are dehydrated). You will not have as much blood flow
    to your skin, so insulin will not be absorbed as well.

Know how to give an insulin injection.

Diabetes: Giving Yourself an Insulin Shot
Diabetes in Children: Giving Insulin Shots to a Child

Side Effects

All medicines have side effects. But many people don’t feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.

Here are some important things to think about:

  • Usually the benefits of the medicine are more important than any minor side effects.
  • Side effects may go away after you take the medicine for a while.
  • If side effects still bother you and you wonder if you should keep taking the medicine, call your doctor. He or she may be able to lower your dose or change your medicine. Do not suddenly quit taking your medicine unless your doctor tells you to.

Call 911 or other emergency services right away if you have:

  • Trouble breathing.
  • Swelling of your face, lips, tongue, or throat.
  • Passed out (lost consciousness), or you suddenly become very sleepy or confused. You may have low blood sugar, called hypoglycemia.

Call your doctor if you have:

  • Hives.
  • Problems with frequent high or low blood sugar levels.

Common side effects of this medicine include:

  • Low blood sugar.

See Drug Reference for
a full list of side effects. (Drug Reference is not available in all

What To Think About

insulin pump provides a way to give insulin with less
frequent injections, and it is as effective as multiple daily injections at keeping
blood sugar levels in a target range.

Don’t share insulin pens with anyone else who uses insulin. Even when the needle is changed, an insulin pen can carry bacteria or blood that can make another person sick.

The long-acting insulin
glargine (Lantus) may help prevent some people from having frequent nighttime
low blood sugar levels. It may also help people who have had
difficulty keeping their blood sugar levels in their target range with
intermediate-acting insulin.

Giving short-acting insulin at the
evening meal and NPH at bedtime instead of giving them together at the evening
meal may reduce the risk of
nocturnal hypoglycemia and
hypoglycemia unawareness.

Things to check

Label each insulin bottle when you use it
for the first time.

Store insulin properly so that its effectiveness is

When you buy insulin, check the generic or brand names
to make sure you are buying the correct type. For example, if you have been
using Humulin R (insulin regular), make sure you buy Humulin R instead of
Humulin N (insulin NPH).

Know when your prescribed types of insulin start working
(onset), when they work most (peak), and how long they work

Taking medicine

Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don’t take your medicines properly, you may be putting your health (and perhaps your life) at risk.

There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.

Advice for women

If you are pregnant, breastfeeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breastfeeding, or planning to get pregnant.


Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It’s also a good idea to know your test results and keep a list of the medicines you take.

Complete the new medication information form (PDF) ( What is a PDF document? ) to help you understand this medication.


Other Works Consulted

  • Centers for Disease Control and Prevention (2007). Guideline for isolation precautions: Preventing transmission of infectious agents in healthcare settings 2007. Available online: ://


ByHealthwise StaffPrimary Medical Reviewer E. Gregory Thompson, MD – Internal Medicine Kathleen Romito, MD – Family Medicine Adam Husney, MD – Family Medicine Specialist Medical Reviewer David C.W. Lau, MD, PhD, FRCPC – Endocrinology Rhonda O’Brien, MS, RD, CDE – Certified Diabetes Educator

Current as ofDecember 7, 2017