Medicine Reaction, Blisters

Many prescription and nonprescription medicines, including some that you put directly on the skin, may cause blisters. A few examples are:

• Antibiotics.
• Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (for example, Advil or Motrin), naproxen (for example, Aleve), or piroxicam (for example, Feldene).
• Medicines you put on your skin (topical medicines), such as Neosporin or benzocaine (for example, Anbesol, Hurricaine, or Orajel), and ethylenediamine, which is used in some topical medicines.
• Seizure medicines.