Disappear without treatment, so follow-up Pap tests would be normal.
Be precancerous and begin to develop into moderate to severe cell changes that eventually may become cancer. Follow-up Pap tests or colposcopy can detect cell changes.
Moderate to severe cell changes
Moderate to severe cervical cell changes (also called moderate to severe dysplasia) mean cell changes that are more likely to be precancerous and develop into cervical cancer if left untreated. Moderate to severe cervical cell changes are classified in the Bethesda system (TBS) as high-grade squamous intraepithelial lesions (HSIL) or atypical glandular cells(AGC). Follow-up evaluation and treatment is needed.
All abnormal Pap tests require follow-up to identify development of more severe cell changes, including cervical cancer. Most abnormal cells can be removed or destroyed before they become cancerous.
ByHealthwise StaffPrimary Medical ReviewerSarah A. Marshall, MD - Family MedicineMartin J. Gabica, MD - Family MedicineKathleen Romito, MD - Family MedicineSpecialist Medical ReviewerKevin C. Kiley, MD - Obstetrics and Gynecology