Topics in Integrative, Alternative, and Complementary Therapies (PDQ®): Integrative, alternative, and complementary therapies - Health Professional Information [NCI]
This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at ://cancer.gov or call 1-800-4-CANCER.
This summary is a list of integrative, alternative, and complementary therapies found on NCI's Cancer.gov website. This summary does not include all integrative, alternative, and complementary therapies.
Complementary and alternative medicine (CAM) covers a wide variety of therapies, botanicals, and dietary supplements. 1]is treatment that is used along with standard treatments but is not considered standard. Alternative medicine is treatment that is used instead of standard treatments. Less research has been done for most types of complementary and alternative medicine than for standard treatments. Integrative therapy is a total approach to medical care that combines standard care with CAM practices. The 2007 National Health Interview Survey reports that about four out of ten adults use a CAM therapy, with the most commonly used treatments being natural products and deep breathing exercises.[
One large survey of cancer survivors reported on the use of complementary therapies. The therapies used most often were and spiritual practice (61%), relaxation (44%), faith and spiritual healing (42%), and nutritional supplements and (40%). CAM therapies are used by 31% to 84% of children with cancer, both inside and outside of .[3,4] CAM therapies have been used in the management of side effects caused by cancer or cancer treatment. Some cancer patients have chosen alternative medicine over conventional treatment, but with a greater risk of death. In Asian countries, traditional Chinese medical therapies are frequently used along with conventional medicine.
One study showed that when CAM was discussed in an oncology visit, it was most often brought up by the patient; and that having such discussions was associated with greater satisfaction with the visit by both patient and physician.
This cancer information summary provides a brief description and a link to integrative, alternative, and complementary therapies found in PDQ summaries or NCI Fact Sheets. The links will take you to the specific PDQ summary, NCI Fact Sheet, or other PDQ summary section, providing more information and references on the topic. Refer to NCI's Office of Cancer Complementary and Alternative Medicine website for links to other resources.
Barnes PM, Bloom B, Nahin RL: Complementary and alternative medicine use among adults and children: United States, 2007. Natl Health Stat Report (12): 1-23, 2009.
Gansler T, Kaw C, Crammer C, et al.: A population-based study of prevalence of complementary methods use by cancer survivors: a report from the American Cancer Society's studies of cancer survivors. Cancer 113 (5): 1048-57, 2008.
Kelly KM: Complementary and alternative medical therapies for children with cancer. Eur J Cancer 40 (14): 2041-6, 2004.
Ndao DH, Ladas EJ, Bao Y, et al.: Use of complementary and alternative medicine among children, adolescent, and young adult cancer survivors: a survey study. J Pediatr Hematol Oncol 35 (4): 281-8, 2013.
Johnson SB, Park HS, Gross CP, et al.: Use of Alternative Medicine for Cancer and Its Impact on Survival. J Natl Cancer Inst 110 (1): , 2018.
Liu JM, Lin PH, Hsu RJ, et al.: Complementary therapy improves survival in patients with metastatic . Medicine (Baltimore) 95 (31): e4475, 2016.
Roter DL, Yost KJ, O'Byrne T, et al.: Communication predictors and consequences of Complementary and Alternative Medicine (CAM) discussions in oncology visits. Patient Educ Couns 99 (9): 1519-25, 2016.
Acupuncture is a part ofpracticed in China and Asia for thousands of years. It has been used clinically to manage cancer-related symptoms, treat side effects induced by chemotherapy or , boost blood cell count, and enhance and natural killer cell activity. In cancer treatment, the primary use of is symptom management; commonly treated symptoms are , chemotherapy-induced nausea and vomiting, and other symptoms that affect a patient's quality of life, including weight loss, anxiety, depression, insomnia, poor appetite, and gastrointestinal symptoms (constipation and diarrhea). Refer to the PDQ summary on for more information.
Botanicals / Herbal Products
Black cohosh is a substance obtained from the root of a perennial herb used in some cultures to treat a number of medical problems. Black cohosh has been studied for reducing. of black cohosh that have been well designed with a randomized placebo-controlled arm have also found that black cohosh is no better than a placebo in reducing . Refer to the Herbs/dietary supplements section in the PDQ summary on and Night Sweats for more information about black cohosh.
Cannabisand Cannabinoids (Also Known as Marijuana)
Cannabis originated in Central Asia but is grown worldwide today. In the United States, it is a controlled substance and is classified as a Schedule I agent (a drug with increased potential for abuse and no known medical use). The Cannabis plant produces a resin containing psychoactive compounds called cannabinoids. The potential benefits of medicinal Cannabis for people living with cancer include antiemetic effects, appetite stimulation, pain relief, and improved sleep. Refer to the PDQ summary on Cannabis and Cannabinoids for more information.
Essiac and Flor Essence are herbal tea mixtures originally developed in Canada. They are marketed worldwide as dietary supplements. Proponents have claimed that Essiac and Flor Essence can help detoxify the body, strengthen the, and fight cancer. No controlled data are available from human studies to suggest that Essiac or Flor Essence can be effective in the treatment of patients with cancer. Refer to the PDQ summary on Essiac/Flor Essence for more information.
Flaxseed comes from the seed of the flax plant and is a rich source of omega-3 fatty acid,, and compounds called lignans. It is being studied in the prevention of several types of cancer. Flaxseed has also been studied for its effect on . Refer to the Herbs/dietary supplements section in the PDQ summary on and Night Sweats for information about that have studied flaxseed.
The roots of the ginger plant have been used in cooking and by some cultures to treat nausea, vomiting, and certain other medical conditions. The plant has been studied for reducing nausea in cancer patients. Refer to the Ginger section in the PDQ summary on Treatment-Related Nausea and Vomiting for information about a randomized controlled trial of ginger in cancer patients.
Ginseng, another popular supplement used to treat, was studied in patients with cancer who were either undergoing anticancer treatment or had completed treatment. There was a significant and clinically meaningful difference favoring the ginseng group over the placebo group. Refer to the Intervention section in the PDQ summary on for more information.
L-carnitine is a dietary supplement believed to be helpful for the treatment of cancer-relatedbecause of its role in cellular energy metabolism and its ability to decrease proinflammatory cytokines. Refer to the Intervention section in the PDQ summary on for information about a phase III study that compared L-carnitine with placebo.
Refer to the PDQ summary on Cannabis and Cannabinoids for more information.
Medicinal mushrooms have been used for hundreds of years, mainly in Asian countries, for the treatment of infections. More recently, medicinal mushrooms have also been used in the treatment of pulmonary diseases and cancer. Refer to the PDQ summary on Medicinal Mushrooms for more information.
is a plant whose fruits have been used for more than 2,000 years as a treatment for liver and biliary disorders. The active substance in is silymarin. Laboratory studies demonstrate that silymarin functions as an antioxidant, stabilizes cellular membranes, stimulates detoxification pathways, stimulates regeneration of liver tissue, inhibits the growth of certain cancer cell lines, exerts direct cytotoxic activity toward certain cancer cell lines, and may increase the efficacy of certain chemotherapy agents. Refer to the PDQ summary on for more information.
Mistletoe is a semiparasitic plant that has been used for centuries to treat numerous human ailments. It is used commonly in Europe, where a variety of different extracts are manufactured and marketed as injectable prescription drugs. These injectable drugs are not available commercially in the United States and are not approved as a treatment for people with cancer. Refer to the PDQ summary on Mistletoe Extracts for more information.
PC-SPES is a patented mixture of eight herbs. Each herb used in PC-SPES has been reported to have anti-inflammatory, antioxidant, or anticarcinogenic properties. PC-SPES was recalled and withdrawn from the market because certain batches were contaminated with Food and Drug Administration–controlled prescription drugs. The manufacturer is no longer in operation, and PC-SPES is no longer being made. Refer to the PDQ summary on PC-SPES for more information.
St. John's wort
It is important that a physician knows what drugs a patient is already using before that patient begins taking, which decreases the effectiveness of other concomitantly administered drugs. There are two important cautions when the use of for is being considered:
- As an herb, 4] the standardization of products such as with respect to the desired amount of potentially is not required by the FDA, but nevertheless carried out by some manufacturers. Therefore, if hyperforin is the desired ingredient, the amount of hyperforin in any formulation of could differ substantially among brands. is regulated by the U.S. Food and Drug Administration (FDA) as a food/dietary supplement. Although the FDA issued a final rule establishing regulations to require manufacturers of dietary supplements to prove good manufacturing processes and to correctly label their ingredients,[
- 5] Clinically, this means that the concomitant use of St. John's wort with other drugs could cause lower concentrations of drugs that are needed to have therapeutic effects. With respect to cancer and its treatment, has been shown to decrease concentrations of irinotecan in patients receiving treatment  and, in vitro, is suspected of reducing concentrations of docetaxel. Additionally, has been found to affect concentrations of cyclosporin A and tacrolimus, both important for transplant engraftment, as well as concentrations of indinavir for the treatment of the . is metabolized within the cytochrome P450 system and has effects inhibiting as well as inducing various metabolic . The affected by are CYP3A4, CYP2C9, and CYP2D6. In one study in humans, effects on systemic concentrations of drugs via the CYP3A4 pathway were evident in as few as 14 days.[
Trials have compared 5];[9,10][Level of evidence: I] Older studies comparing St. John's wort with antidepressant therapy tended to use low doses of , and the doses of did not titrate up by response to the usual doses used for managing depression. The best overview of the research in this area is provided in a meta-analysis of randomized . Conclusions from this meta-analysis, which includes 37 trials, are that does not have a clinically important effect on major depressive and that for milder , it may have some effect (but the effect is not large).with placebo, with , and sometimes with both placebo and antidepressants. A wide range of results have emerged, from finding no differences between arms, to finding improving outcomes over placebo for moderate , to finding preferable to placebo in general, to finding equal to in alleviating depressive symptoms.[
Side effects reported in studies of 11][Level of evidence: I] According to a meta-analysis of randomized , fewer patients treated with St. John's wort withdrew from trials because of adverse effects than did those treated with .are minimal. One study that compared with sertraline and placebo found that the side effects of , which were significantly different from those of placebo, included anorgasmia, frequent urination, and swelling.[
The bottom line regarding the use offor the management of is that, despite a more tolerable side effect profile, there is some, but currently no unambiguous evidence demonstrating an advantage to using this herbal agent over approved antidepressant therapy. The data do not support a strong effect on major depressive or even on mild to moderate . This fact, combined with concerns about drug interactions and lack of uniformity in standardization, limits the evidence which supports as being effective for depression management specifically in cancer patients.
Selected Vegetables/Sun's Soup
"Selected Vegetables" and "Sun's Soup" are names given to several different mixtures of vegetables and herbs that have been studied as treatments for cancer. These mixtures were developed by a single individual. Two formulations of Selected Vegetables/Sun's Soup are marketed in the United States as dietary supplements. The vegetables and herbs in Selected Vegetables/Sun's Soup are thought to have anticancer and/or immune-system–stimulating properties. Existing data supporting the effectiveness of Selected Vegetables/Sun's Soup as a treatment for cancer are limited and weak. Refer to the PDQ summary on Selected Vegetables/Sun's Soup for more information.
Memorial Sloan-Kettering Cancer Center Integrative Medicine Service: About Herbs, Botanicals & Other Products: . New York, NY: Memorial Sloan-Kettering Cancer Center, 2014. Available online. Last accessed October 26, 2017.
National Center for Complementary and Integrative Health: Get the Facts: and Depression. Bethesda, Md: National Institutes of Health, 2013. NCCIH Pub. No. D005. Also available online. Last accessed October 26, 2017.
Franklin M, Cowen PJ: Researching the antidepressant actions of Hypericum perforatum (St. John's wort) in animals and man. Pharmacopsychiatry 34 (Suppl 1): S29-37, 2001.
U.S. Food and Drug Administration: FDA Issues Dietary Supplements Final Rule. Silver Spring, Md: U.S. Food and Drug Administration, 2007. Available online. Last accessed October 26, 2017.
Markowitz JS, Donovan JL, DeVane CL, et al.: Effect of on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA 290 (11): 1500-4, 2003.
Mathijssen RH, Verweij J, de Bruijn P, et al.: Effects of on irinotecan . J Natl Cancer Inst 94 (16): 1247-9, 2002.
Komoroski BJ, Parise RA, Egorin MJ, et al.: Effect of the constituent hyperforin on docetaxel metabolism by human hepatocyte cultures. Clin Cancer Res 11 (19 Pt 1): 6972-9, 2005.
Mansky PJ, Straus SE: : more implications for cancer patients. J Natl Cancer Inst 94 (16): 1187-8, 2002.
Mannel M, Kuhn U, Schmidt U, et al.: extract LI160 for the with atypical features - a double-blind, randomized, and placebo-controlled trial. J Psychiatr Res 44 (12): 760-7, 2010.
Linde K, Berner M, Egger M, et al.: for : meta-analysis of randomised controlled trials. Br J Psychiatry 186: 99-107, 2005.
Hypericum Depression Trial Study Group: Effect of Hypericum perforatum ( ) in major depressive : a randomized controlled trial. JAMA 287 (14): 1807-14, 2002.
Mind-Body Therapies and Massage
Aromatherapy and Essential Oils
Aromatherapy is the therapeutic use of essential oils (also known as volatile oils) from plants (flowers, herbs, or trees) for the improvement of physical, emotional, and spiritual well-being. Aromatherapy is used by cancer patients primarily as supportive care for general well-being, and with other complementary treatments (e.g., massage and acupuncture) and standard treatment. Refer to the PDQ summary on Aromatherapy and Essential Oils for more information.
Cognitive-Behavioral Therapy (CBT)
CBT is a type of psychotherapy that helps patients change behavior by changing the way they think and feel about certain things. It is used to treat mental, emotional, personality, and behavioral.
The efficacy of CBT has been studied for. Refer to the Nonpharmacologic Management of Sleep Disturbances section in the PDQ summary on Sleep Disorders for more information about cognitive behavioral interventions used for .
Relaxation therapy and imagery have been used to treat anticipatory nausea and vomiting. Refer to the Treatment of Anticipatory Nausea and Vomiting section in the PDQ summary on Treatment-Related Nausea and Vomiting for more information about behavioral interventions used in the treatment of anticipatory nausea and vomiting.
Cognitive-behavioral psychotherapy has been used to treatand has been offered in a variety of forms. Most interventions have been offered in both individual and small-group formats and have included a structured educational component about cancer or a specific relaxation component. Refer to the Psychotherapy section in the PDQ summary on for more information about psychotherapy for . Refer to the Treatment section in the PDQ summary on Cancer-Related Post-traumatic Stress for more information about the use of CBT for post-traumatic symptoms.
Hypnosis is a trance-like state in which one becomes more aware and focused and is more open to suggestion. Under, a person can concentrate more clearly on a specific thought, feeling, or sensation without becoming distracted. Refer to the Psychosocial Interventions for Distress section in the PDQ summary on Adjustment to Cancer: Anxiety and Distress for information on a study about used for presurgical distress.
Qigong is a component of 1] Refer to the Exercise section in the PDQ summary on for more information about how qigong is being studied in cancer-related .that combines movement, meditation, and controlled breathing. The intent is to improve blood flow and the flow of qi. Some trials, mostly with small sample sizes, have indicated that qigong may improve quality of life and fatigue in cancer patients.[
Spirituality and religion are important to most individuals in the general population, according to national surveys. In health care, concerns about spiritual or religious well-being have sometimes been viewed as an aspect of complementary and alternative medicine, but this perception may be more characteristic of providers than of patients. Refer to the PDQ summary on Spirituality in Cancer Care for information about religion, spirituality, spiritual well-being, and health.
Some trials, mostly with small sample sizes, have indicated that tai chi may improve quality of life and fatigue in cancer patients. A study that compared CBT with a manualized form of Tai Chi (Tai Chi Chih) for the treatment of in 90 survivors found improvements in in both and no significant difference between the two therapies. Refer to the PDQ summary on in Adults with Non− Cancers for more information about how Tai Chi is being studied in .
3] One study revealed lower levels of fatigue and inflammation in survivors participating in a yoga program. Refer to the for survivors of section in the PDQ summary on Adjustment to Cancer: Anxiety and Distress for information about a that used meditation and yoga to reduce in survivors.is an ancient system of practices used to balance the mind and body through movement, (focusing thoughts), and control of breathing and emotions. is being studied as a way to relieve stress and poor sleep in cancer patients.[
Zeng Y, Luo T, Xie H, et al.: Health benefits of qigong or tai chi for cancer patients: a systematic review and meta-analyses. Complement Ther Med 22 (1): 173-86, 2014.
Irwin MR, Olmstead R, Carrillo C, et al.: Tai Chi Chih Compared With for the Treatment of in Survivors of : A Randomized, Partially Blinded, Noninferiority Trial. J Clin Oncol 35 (23): 2656-2665, 2017.
Pan Y, Yang K, Wang Y, et al.: Could yoga practice improve treatment-related side effects and quality of life for women with ? A systematic review and meta-analysis. Asia Pac J Clin Oncol 13 (2): e79-e95, 2017.
Kiecolt-Glaser JK, Bennett JM, Andridge R, et al.: 's impact on , mood, and in survivors: a randomized controlled trial. J Clin Oncol 32 (10): 1040-9, 2014.
and Cancer Prevention
are substances that may protect cells from the damage caused by unstable molecules known as . Free radical damage may lead to cancer. interact with and stabilize and may prevent some of the damage free radicals might otherwise cause. There has been some concern about whether may decrease the effectiveness of chemotherapy and . Examples of include beta-carotene; lycopene; vitamins C, E, and A; and other substances. Refer to the NCI Fact Sheet on and Cancer Prevention for more information about .
is made naturally by the human body. helps cells to produce energy, and it acts as an . has shown an ability to stimulate the and to protect the heart from damage caused by certain chemotherapy drugs. No report of a randomized of as a treatment for cancer has been published in a peer-reviewed scientific journal. Refer to the PDQ summary on for more information.
Many studies suggest that the use of complementary and alternative medicine is common among many cancer patients, and the use of, supplements, and specific foods is frequently reported by patients. Refer to the PDQ summary on , Nutrition, and Dietary Supplements for information about green tea, lycopene, modified citrus pectin (MCP), pomegranate, soy, and Zyflamend supplements used by some patients.
The Gerson therapy is advocated by its supporters as a method of treating cancer patients based on changes in diet and nutrient intake. An organic vegetarian diet plus nutritional and biological supplements, pancreatic, and coffee or other types of are the main features of the Gerson therapy. Few of the Gerson therapy are found in the medical literature. Refer to the PDQ summary on the Gerson Therapy for more information.
Glutamine is anthat is important for gastrointestinal (GI) mucosal cells and their replication. These cells are often damaged by chemotherapy and , causing mucositis and diarrhea, which can lead to treatment delays, dose reductions, and severely affect quality of life. Some evidence suggests that oral glutamine can reduce both of those toxicities by aiding in faster healing of the mucosal cells and the entire GI tract. Refer to the Nutrition Trends in Cancer section in the PDQ summary on Nutrition in Cancer Care for information on trials that studied oral glutamine.
The Gonzalez regimen is a complex cancer treatment that is tailored by the practitioner for each specific patient and is currently available only to the patients of its developer. Pancreatictaken orally are the primary agents in the regimen thought to have direct antitumor effects. The regimen also includes specific diets, vitamin and mineral supplements, extracts of animal organs, and coffee enemas. Refer to the PDQ summary on the Gonzalez Regimen for more information.
Lycopene is a carotenoid found in a number of fruits and vegetables, including apricots, guava, and watermelon, but most of the lycopene consumed in the United States comes from tomato-based products. When ingested, lycopene is broken down into a number of metabolites and is thought to have various biological functions, including antioxidant capabilities. Lycopene has been investigated for its role in chronic diseases, including cardiovascular disease and cancer. Refer to the Lycopene section in the PDQ summary on, Nutrition, and Dietary Supplements for more information.
Melatonin is aproduced by the during the hours of darkness, plays a major role in the sleep-wake cycle, and is linked to the . in renal, breast, colon, lung, and brain cancer suggest that melatonin exerts anticancer effects in conjunction with chemotherapy and ; however, evidence remains inconclusive. Refer to the Botanical/dietary supplements section in the PDQ summary on Sleep Disorders for information about how is being studied in sleep disturbances. Refer to the Nutrition Trends in Cancer section in the PDQ summary on Nutrition in Cancer Care for information on how is being studied with chemotherapy or .
Modified Citrus Pectin (MCP)
Citrus pectin is a complex polysaccharide found in the peel and pulp of citrus fruit and can be modified by treatment with high pH and temperature. MCP may have effects on cancer growth and metastasis through multiple potential mechanisms, as suggested in preclinical research. Some research suggests that MCP may be protective against various types of cancer, including colon, lung, and. Refer to the Modified Citrus Pectin section in the PDQ summary on , Nutrition, and Dietary Supplements for more information.
The pomegranate (Punica granatum L.) plant is native to Asia and cultivated widely throughout the world. Various components of the pomegranate fruit contain bioactive compounds, including phenolics, flavonoids, and anthocyanins, some of which have antioxidant activity. Pomegranate extracts have been shown to inhibit the proliferation of humancells in vitro. Refer to the Pomegranate section in the PDQ summary on , Nutrition, and Dietary Supplements for more information.
are nutritional supplements that contain a defined amount of viable microorganisms. The use of probiotic functional foods (beneficial live microorganisms) to modify gut microflora has been suggested for clinical conditions associated with diarrhea, gut-barrier dysfunction, and inflammatory response. Refer to the Management section in the PDQ summary on Gastrointestinal Complications for information about . Refer to the Nutrition Trends in Cancer section in the PDQ summary on Nutrition in Cancer Care for information on trials that used before .
Selenium is an essential trace mineral involved in a number of biological processes, including enzyme regulation, gene expression, and immune function. Selenium is being studied for its role in cancer. Refer to the Selenium section in the PDQ summary on, Nutrition, and Dietary Supplements for information about studies investigating the effects of selenium on .
Soy comes from a plant of Asian origin that produces beans used in many food products. Soy foods (e.g., soy milk, miso, tofu, and soy flour) containthat may have health benefits and, among these, soy isoflavones have been the focus of most of the research. Soy is being studied for the prevention of cancer, that occur with , and osteoporosis (loss of ). Refer to the Integrative Approaches section in the PDQ summary on and Night Sweats for information about the use of soy in patients. Refer to the Soy section in the PDQ summary on , Nutrition, and Dietary Supplements for information about studies investigating the effects of soy on .
Tea has long been regarded as anto good health, and many believe it can help reduce the risk of cancer. Tea originates from the plant Camellia sinensis, and contains polyphenol compounds, particularly catechins, which are and whose biological activities may be relevant to cancer prevention. Refer to the NCI Fact Sheet on Tea and Cancer Prevention: Strengths and Limits of the Evidence for information about tea and cancer prevention.
Some observational and interventional studies suggest that green tea may have a protective effect against cardiovascular disease, and there is evidence that green tea may protect against various forms of cancer. Refer to the Green Tea section in the PDQ summary on, Nutrition, and Dietary Supplements for more information about studies investigating the effects of green tea on .
Vitamin C, High-Dose
Vitamin C (ascorbic acid) is an essentialthat has antioxidant functions, is a cofactor for several , and plays an important role in the synthesis of . High-dose vitamin C has been studied as a treatment for cancer patients. Refer to the PDQ summary on High-Dose Vitamin C for more information.
is involved in a number of processes that are essential for good health. is produced by the body in response to sunlight exposure. It can also be obtained through the diet, but very few foods naturally contain vitamin D. These foods include fatty fish, fish liver oil, and eggs. Refer to the NCI Fact Sheet on and Cancer Prevention for information about scientific studies that have investigated the possible role of in cancer prevention. Refer to the section in the PDQ summary on , Nutrition, and Dietary Supplements for information about studies investigating the effects of on .
Vitamin E is athat the body needs in small amounts to stay healthy and work the way it should. It is fat-soluble (can dissolve in fats and oils) and is found in seeds, nuts, leafy green vegetables, and vegetable oils. Vitamin E boosts the and helps keep blood clots from forming. It also helps prevent cell damage caused by free radicals (highly reactive chemicals). Vitamin E is being studied in the prevention and treatment of some types of cancer. It is a type of antioxidant, also called alpha-tocopherol. Refer to the Vitamin E section in the PDQ summary on , Nutrition, and Dietary Supplements for information about studies investigating the effects of vitamin E on . Refer to the Herbs/dietary supplements section in the PDQ summary on and Night Sweats for information about and vitamin E studies.
714-X is naturally derived camphor that is chemically modified by the introduction of a nitrogen atom. It is claimed that 714-X protects and stabilizes theand restores its ability to fight cancer. No study of 714-X has been published in a peer-reviewed scientific journal to show its safety or effectiveness in treating cancer. Refer to the PDQ summary on 714-X for more information.
Antineoplastons are drugs composed of chemical compounds that are naturally present in the urine and blood. They are an experimental cancer therapy that is purported to provide a natural biochemical substance that is excreted and therefore lacking in people with cancer. Antineoplastons therapy for cancer patients is currently available only in the United States and only to the patients of its developer. Refer to the PDQ summary on Antineoplastons for more information.
Cancell/Cantron/Protocel—also known by the names Sheridan's Formula, Jim's Juice, JS-114, JS-101, 126-F, and the "Cancell-like" products Cantron and Protocel—is a liquid that has been produced in various forms principally by two manufacturers since the late 1930s. The exact composition of Cancell/Cantron/Protocel is unknown and not effective in treating any type of cancer. Refer to the PDQ summary on Cancell/Cantron/Protocel for more information.
(Bovine and Shark)
Bovine (cow)and shark have been studied as treatments for people with cancer and other medical conditions for more than 30 years. At least three different inhibitors of angiogenesis have been identified in bovine , and two angiogenesis inhibitors have been purified from shark . Refer to the PDQ summary on (Bovine and Shark) for more information.
Hydrazine sulfate is a chemical that has been studied as a treatment for cancer and as a treatment for the body wasting (i.e., cachexia) associated with this disease. It has been claimed that hydrazine sulfate limits the ability of tumors to obtain glucose, which is a type of sugar used by cells to create energy. Refer to the PDQ summary on Hydrazine Sulfate for more information.
Laetrile is another name for the chemical amygdalin, which is found in the pits of many fruits and in numerous plants. Cyanide is thought to be the main anticancer component of laetrile. Laetrile has shown little anticancer activity in animal studies and no anticancer activity in human. Refer to the PDQ summary on Laetrile/Amygdalin for more information.
Newcastle Disease Virus (NDV)
NDV is a paramyxovirus that causes Newcastle disease in a wide variety of birds (most notably, in chickens). Although NDV causes a potentially fatal, noncancerous disease (Newcastle disease) in birds, it causes only minor illness in humans. NDV appears to replicate (i.e., reproduce) substantially better in human cancer cells than it does in most normal human cells. Refer to the PDQ summary on Newcastle Disease Virus for more information.
Changes to This Summary (06 / 22 / 2018)
The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.
Mind-Body Therapies and Massage
Added text about a study that compared Tai Chi Chih withfor the treatment of in survivors of (cited Irwin et al. as reference 2).
This summary is written and maintained by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ® - NCI's Comprehensive Cancer Database pages.
About This PDQ Summary
Purpose of This Summary
This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the complementary and alternative therapies found in other PDQ summaries and NCI Fact Sheets. It is intended as a resource to inform and assist clinicians who care for cancer patients. It does not provide formal guidelines or recommendations for making health care decisions.
Reviewers and Updates
This summary is reviewed regularly and updated as necessary by the PDQ Integrative, Alternative, and Complementary Therapies Editorial Board, which is editorially independent of the National Cancer Institute (NCI). The summary reflects an independent review of the literature and does not represent a policy statement of NCI or the National Institutes of Health (NIH).
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The lead reviewers for Topics in Integrative, Alternative, and Complementary Therapies are:
- Jinhui Dou, PhD (Food and Drug Administration)
- Jing Li, PhD (Food and Drug Administration)
- Gabriel Lopez, MD (MD Anderson Cancer Center)
- Weidong Lu, MB, PhD, MPH (Dana-Farber Cancer Institute)
- Jeffrey D. White, MD (National Cancer Institute)
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Levels of Evidence
Some of the reference citations in this summary are accompanied by a level-of-evidence designation. These designations are intended to help readers assess the strength of the evidence supporting the use of specific interventions or approaches. The PDQ Integrative, Alternative, and Complementary Therapies Editorial Board uses a formal evidence ranking system in developing its level-of-evidence designations.
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PDQ® Integrative, Alternative, and Complementary Therapies Editorial Board. PDQ Topics in Integrative, Alternative, and Complementary Therapies. Bethesda, MD: National Cancer Institute. Updated <MM/DD/YYYY>. Available at: ://www.cancer.gov/about-cancer/treatment/cam/hp/cam-topics-pdq. Accessed <MM/DD/YYYY>. [PMID: 26389506]
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Last Revised: 2018-06-22