Acquired von Willebrand Disease

Acquired von Willebrand Disease

Topic Overview

Acquired von Willebrand disease is a rare bleeding
disorder that might be caused by other medical problems or medicines. It prevents blood from clotting
properly. It is rarer than the inherited form of
von Willebrand disease.

Medical problems that might cause acquired von Willebrand disease include:

Rarely, acquired von Willebrand disease may also develop in direct
association with use of certain medicines. When use is discontinued, signs of
the disease also end. These medicines include:

  • Ciprofloxacin.
  • Griseofulvin.
  • Valproic acid.

Symptoms include
nosebleeds with no previous history of bleeding

Treatment of acquired von Willebrand disease includes medicines that help your body have enough von Willebrand clotting factor in
the blood. This von Willebrand factor helps your blood clot.

Related Information


Other Works Consulted

  • Hillman R, et al. (2011). Platelet dysfunction and von Willebrand disease. In Hematology in Clinical Practice, 5th ed., pp. 384–397. New York: McGraw-Hill.
  • National Heart, Lung, and Blood Institute (2007). The Diagnosis, Evaluation, and Management of von Willebrand Disease. (NIH Publication No. 08–5832). Available online:
  • Nichols WL (2016). Von Willebrand disease and hemorrhagic abnormalities of platelet and vascular function. In L Goldman, A Shafer, eds., Goldman-Cecil Medicine, 24th ed., vol. 1, pp. 1167–1172. Philadelphia: Saunders.


ByHealthwise StaffPrimary Medical Reviewer E. Gregory Thompson, MD – Internal Medicine Adam Husney, MD – Family Medicine Martin J. Gabica, MD – Family Medicine Kathleen Romito, MD – Family Medicine Specialist Medical Reviewer Brian Leber, MDCM, FRCPC – Hematology

Current as ofFebruary 23, 2018