DHEA-S Test
Test Overview
DHEA-S (dehydroepiandrosterone sulfate) is a male hormone (androgen) that is made in the adrenal glands. The body turns it into testosterone. A test for DHEA-S checks the level of this hormone in the blood.
Testosterone affects sexual features and development. In men, it is made in large amounts by the testicles. In both men and women, testosterone is made in small amounts by the adrenal glands. In women, small amounts are made by the ovaries.
Why It Is Done
This test is usually done along with tests of other hormone levels. DHEA-S might be tested to:
- Look for the cause of facial hair, a deep voice, or other signs of too much male hormone in a girl or woman. It may be one of the tests done to diagnose polycystic ovary syndrome.
- To help find other conditions, such as:
- Congenital adrenal hyperplasia. This is a condition that causes the adrenal glands to make too much male sex hormone.
- Infertility.
- Delayed puberty.
- Cushing’s disease.
- A tumor in an adrenal gland.
How To Prepare
If your doctor tells you to fast before your test, do not eat or drink anything except water for 9 to 12 hours before you have your blood drawn. In most cases, you are allowed to take your medicines with water the morning of the test.
The test is usually done in the morning, because that is when the amount of DHEA-S is at its highest.
Women may be asked to take the test at a certain time in their menstrual cycle.
How It Is Done
The health professional taking a sample of blood will:
- Wrap an elastic band around your upper arm to stop the flow of blood. This makes the veins below the band larger so it is easier to put a needle into the vein.
- Clean the needle site with alcohol.
- Put the needle into the vein. More than one needle stick may be needed.
- Attach a tube to the needle to fill it with blood.
- Remove the band from your arm when enough blood is collected.
- Put a gauze pad or cotton ball over the needle site as the needle is removed.
- Put pressure on the site and then put on a bandage.
How It Feels
The blood sample is taken from a vein in your arm. An elastic band is wrapped around your upper arm. It may feel tight. You may feel nothing at all from the needle, or you may feel a quick sting or pinch.
Risks
There is very little chance of a problem from having a blood sample taken from a vein.
- You may get a small bruise at the site. You can lower the chance of bruising by keeping pressure on the site for several minutes.
- In rare cases, the vein may become swollen after the blood sample is taken. This problem is called phlebitis. A warm compress can be used several times a day to treat this.
Results
The normal values listed here—called a reference range—are just a guide. These ranges vary from lab to lab, and your lab may have a different range for what’s normal. Your lab report should contain the range your lab uses. Also, your doctor will evaluate your results based on your health and other factors. This means that a value that falls outside the normal values listed here may still be normal for you or your lab.
|
Women before menopause |
|
|
Women after menopause |
Less than 130 mcg/dL or 100 to 610 ng/mL |
|
Pregnant women (full term) |
230 to 1,170 ng/mL |
|
Adult male |
130 to 550 mcg/dL or 270 to 1,400 ng/dL |
|
Male before puberty |
2,000 to 3,350 ng/mL |
|
Child |
100 to 600 ng/dL |
|
Newborn |
1,670 to 3,640 ng/mL |
High values
Levels of DHEA may be high because you have:
- Stress.
- Cushing’s disease.
- A tumor in an adrenal gland. It may not be serious, although it could be cancer.
- Hyperthyroidism.
- Polycystic ovary syndrome.
- Congenital adrenal hyperplasia. This is a condition that causes the adrenal glands to make too much male sex hormone.
Low values
Levels of DHEA may be low because:
- In males, the adrenal glands are not making enough male sex hormones (androgens).
- In women, the ovaries are not making enough female sex hormones (estrogen).
- An adrenal gland has a tumor.
- You have a condition such as Crohn’s disease or ulcerative colitis.
What Affects the Test
You may not be able to have the test, or the results may not be helpful, if you:
- Have had a radioactive scan done within a week of the test. This may increase DHEA-S levels.
- Use corticosteroids. This may reduce the level of DHEA-S.
- Use certain medicines, such as phenytoin, carbamazepine, amlodipine, or antidepressants.
- Take DHEA supplements, which can increase the level of DHEA-S.
- Do intense exercise, such as running a marathon. It can increase DHEA levels for a few days.
What To Think About
Levels of DHEA-S are normally high in newborns. They are lower in childhood and then rise again in puberty.
Current as of: November 6, 2018
Author: Healthwise Staff
Medical Review:Sarah A. Marshall, MD – Family Medicine & E. Gregory Thompson, MD – Internal Medicine & Kathleen Romito, MD – Family Medicine & Adam Husney, MD – Family Medicine & Anne C. Poinier, MD – Internal Medicine
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